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RESEARCH INTERESTS

1.    Resistance Mechanisms & New Drug Development for EGFR-Targeted Therapy

2.    Molecular Regulation & Drug Development for Targeting Cancer Organoids

3.    Selective Autophagy Receptors in Cancer Progression

4.    Selective Autophagy Pathways of Nanodiamonds & Nanodrugs

                                                                                                                                     

RESEARCH SUPPORTS

Title of research project: Targeting PDL1 of cancer cells and its functions using novel nanodiamond-PDL1 antibody complexes. Grant number: VGHUST107-G1-6-2, Taipei Veterans General Hospital-UST, 2018/01/01-2018/12/31 (Principal Investigator)

Title of research project: A novel compound SP101 in overcoming drug resistance of non-small cell lung carcinoma and cancer therapeutic efficacy. Grant number: MOST 106-2320-B-009-001-MY3, Ministry of Science and Technology, ROC, 2017/08/01-2020/7/31 (Principal Investigator)

Title of research project: The efficacy and drug resistance mechanism of AZD9291 in non-small cell lung cancer. Grant number: 106W970/106-HCH074, National Taiwan University Hospital Hsin-Chu Branch-NCTU Collaboration, 2017/01/01-2017/12/31 (Principal Investigator)

Title of research project: Binding interaction, bio-activity, molecular imaging and the conquest of drug resistance on the epidermal growth factor receptor of cancer cell using fluorescent nanodiamond-conjugated targeting molecules. Grant number: MOST 103-2627-M-009 -004, 2014/08/01-2017/7/31 (Principal Investigator)

Title of research project: Investigation of novel EGFR inhibitors on the therapeutic efficacy and the overcoming drug resistance in NSCLC. Grant number: MOST 103-2320-B-009-003-MY3, 2014/08/01-2017/07/31 (Principal Investigator)

Title of research project: Labeling and therapy on the epidermal growth factor receptor of colon cancer cells using nanodiamonds. Grant number: 103W970, Mackay Memorial Hospital-NCTU Collaboration, 2014/01/01-2014/12/31 (Principal Investigator)

Title of research project: Labeling and therapy of cancer stem cells using novel chitosan-nanodiamond complexes. (2014/01/01-2014/12/31) (Grant number: VGHUST103-G5-4-3) (Principal Investigator)

Title of research project: Development of novel nanodiamond complexes and its applications in cancer and neuron systems. Grant number 102W976, National Chiao Tung University, Taiwan, 2013-2014 (Principal Investigator)

Title of research project: Manipulation of nanodiamonds in targeting therapy of colon cancer. Grant number 102W970, Mackay Memorial Hospital-NCTU Collaboration, 2013-2014 (Principal Investigator)

Title of research project: Biocompatibility and application of nanodiamond in cardiovascular system. Grant number 101TMUH-NCTU-001, TMUH-NCTU Collaboration, 2012-2013 (Principal Investigator)

Title of research project: Development of chemically modified nanodiamonds for siRNA delivery and for quantitative and specific detection of biological relevant molecules and pathogens. Academia Sinca-Israel Collaboration, 2012-2014 (Co-Principal Investigator)

Title of research project: Verification of biochemical and pharmacological activities by predicting and screening compounds. Grant numbers NSC 100-2627-B-009-007, NSC 101-2627-B-009-007, NSC 102-2627-B-009-007, National Science Council, Taiwan, 2011-2014 (Principal Investigator)

Title of research project: Preparation and biomedical applications of multi-functional drug nanocarriers. Grant number 100W976, National Chiao Tung University, Taiwan, 2011-2013 (Principal Investigator)

Title of research project: Molecular endocytic mechanisms, chase, separation and applications of diamond nanoparticles in human cancerous cell and xenograft tumor mouse models. Grant Number NSC 99-2311-B-009-003-MY3, National Science Council, Taiwan, 2010-2013 (Principal Investigator)

Title of research project: The preparation, characterization, manipulation and applications of target-specific nanodiamond-biomolecule/drug composites. Grant Numbers NSC 97-2120-M-259-002, NSC 98-2120-M-259-001, NSC 99-2120-M-259-001, National Science Council, Taiwan, 2008-2011 (Co-Principal Investigator)

Title of research project: Mechanisms of cytoskeleton alteration and cell death by a brand-new compound PT-262. Grant Number NSC 96-2311-B-009-003-MY3, National Science Council, Taiwan, 2007-2010 (Principal Investigator)

Title of research project: Anticancer ability of medicinal herbal ingredients: Effect on lung cancer cell and survivin. Grant Numbers NSC 94-2745-B-320-006-URD, NSC 95-2745-B-320-007-URD, NSC 96-2745-B-320-002-URD, National Science Council, Taiwan, 2005-2008 (Principal Investigator)

Title of research project: Nano-diamond-protein complex development, manipulation and applications in biological and medical systems. Grant Numbers NSC 94-2120-M-259-002, NSC 95-2120-M-259-003, NSC 96-2120-M-259-002, National Science Council, Taiwan, 2005-2008 (Co-Principal Investigator)

Title of research project: Effects of the survivin gene knockdown on mitotic progression and anti-cancer ability in human lung carcinoma cells: in vitro and in vivo study. Grant Number NSC 94-2320-B-320-020, National Science Council, Taiwan, 2005-2006 (Principal Investigator)

Title of research project: Nano-science and technology research center in Eastern Taiwan. Grant Numbers NSC 94-2120-M-259-003, NSC 95-2120-M-259-002, NSC 96-2120-M-259-001, National Science Council, Taiwan, 2005-2008 (Co-Principal Investigator)

Title of research project: The anticancer ability of bioflavonoids: the effects of cancer cells and target protein survivin. Grant Number DOH 93TDF113052-2, Department of Health, Executive Yuan, Taiwan, 2004-2005 (Principal Investigator)

Title of research project: The relationship between expression of inhibitor of apoptosis protein (IAP) survivin and carcinogenesis induced by arsenite: The models of normal and lung cancer cells. Grant Number NSC 93-2320-B320-014, National Science Council, Taiwan, 2004-2005 (Principal Investigator)