Principle Investigator


Research Interests





Research Rules


JOURNAL PAPERS (2004~PRESENT, *CORRESPONDING AUTHOR, Times Cited from Google scholar)

Lin, YW, Raj, EN, Liao, WS, Lin, J, Liu, KK, Chen, TH, Cheng, HC, Wang, CC, Li, LY, Chen, C and Chao, JI* (2017) Co-delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibition. Scientific Reports, 7: 9814.

Boobalan, R, Liu, KK, Chao, JI*, and Chen, C* (2017) Synthesis and biological assay of erlotinib analogues and BSA-conjugated erlotinib analogue. Bioorganic & Medicinal Chemistry Letters, 27:1784-1788. 

Liu, KK, Qiu, WR, Raj, EN, Liu, HF, Huang, HS, Lin, YW, Chang, CJ, Chen, TH, Chen, C, Chang, HC, Hwang, JK, and  Chao, JI* (2017) Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway. Autophagy, 13: 187-200.

Wang, YJ, Larsson, M, Chiou, SH, Nicholls, SJ, Chao, JI, and Liu, DM* (2016) The use of polymer-based nanoparticles and nanostructured materials in treatment and diagnosis of cardiovascular diseases: Recent advances and emerging designs. Progress in Polymer Science, 57: 153-178.

Chang, CW, Yu, JC, Hsieh, YH, Chen, PM, Chao, JI, Yao, CC, Hsiung, CN, Chu, HW, Shen, CY, and Cheng, CW* (2016) MicroRNA-30a increases tight junction protein expression to suppress the epithelial-mesenchymal transition by repressing its target gene Slug in breast cancer. Oncotarget, 7: 16462-16478.

Hsieh, YH, Liu, KK, Sulake, RS, Chao, JI*, and Chen, C* (2015) Microwave-assisted efficient conjugation of nanodiamond and paclitaxel. Bioorganic & Medicinal Chemistry Letters, 25: 2074-2077.

Huang, YA, Kao, CW, Liu, KK, Huang, HS, Chiang, MH, Soo, CR, Chang, HC, Chiu, TZ*, Chao, JI*, and Hwang, E* (2014) The effect of fluorescent nanodiamonds on neuronal survival and morphogenesis. Scientific Reports, 4: 6919. 

Yin, KH, Hsieh, YH, Sulake, RS, Wang, SP, Chao, JI*, and Chen, C* (2014) Optimization of the gefitinib analogues with potent anticancer activity. Bioorganic & Medicinal Chemistry Letters, 24: 5247-5250. 

Vankayala, R, Chiang, CS, Chao, JI, Yuan, CJ, Lin, SY, Hwang, KC (2014) A general strategy to achieve ultra-high gene transfection efficiency using lipid-nanoparticle composites. Biomaterials, 35: 8261-8272. 

Lai, YJ, Lin, CI, Wang, CL, and Chao, JI* (2014) Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells. Journal of Cellular Biochemistry, 115:1888-1899. 

Huang YT, Lin, CI, Chien, PH, Tang, TT, Lin, J and Chao, JI* (2014) The depletion of securin enhances butein-induced apoptosis and tumor inhibition in human colorectal cancer. Chemico-Biological Interactions, 220: 41-50. 

Hsu, TC, Liu, KK, Chang, HC, Hwang, E, and Chao, JI* (2014) Labeling of neuronal differentiation and neuron cells using fluorescent nanodiamonds. Scientific Reports, 4: 5004. 

Yang, CR, Liao, WS, Wu, YH, Murugan , K, Chen, C*, and Chao, JI* (2013) CR108, a novel vitamin K3 derivative induces apoptosis and breast tumor inhibition by reactive oxygen species and mitochondrial dysfunction. Toxicology and Applied Pharmacology, 273: 611-622.

Yu, SY, Liu, HF, Wang, SP,Chang, CC, Tsai, CM, and Chao, JI* (2013) Evidence of securin-mediated resistance of gefitinib-induced apoptosis in human cancer cells. Chemico-Biological Interactions, 203:412-422.

Vaijayanthimala,, Cheng, P, Yeh, SH, Liu, KK, Hsiao, CH*, Chao, JI*, and Chang, HC* (2012) The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo imaging contrast agent. Biomaterials, 33: 7794-7802. (Times Cited 130+)

Lien, ZY, Hsu, TC, Liu, KK, Liao, WS, Hwang, KC, and Chao, JI* (2012) Cancer cell labeling and tracking using fluorescent and magnetic nanodiamond. Biomaterials, 33:6172-6185. 

Cheng, CW*, Wang, HW, Chang, CW, Chu, HW, Chen, CY, Yu, JC, Chao, JI, Liu, HF, Ding, SL, and Shen, CY (2012) MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer. Breast Cancer Research and Treatment, 134: 1081-93. (Times Cited 130+)

Wang, G, Gao, Y, Li, L, Jin, G, Zhen C, Chao, JI, Lin, HK* (2012) K63-linked ubiquitination in kinase activation and cancer. Frontiers in Molecular and Cellular Oncology, 2: 1-13.

Tsai, CC, Liu, HF, Hsu, KC, Yang, JM, Chen, C, Liu, KK, Hsu, TS, and Chao, JI* (2011) 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration. Biochemical Pharmacology, 81: 856-865. 

Liu, HF, Hu, HC, and Chao, JI* (2010) Oxaliplatin down-regulates survivin by p38 MAP kinase and proteasome in human colon cancer cells. Chemico-Biological Interactions, 188: 535-545. 

Liu, KK, Zheng WW, Wang CC, Chiu, YC, Cheng, CL, Lo YS, Chen, C, and Chao, JI* (2010) Covalent linkage of nanodiamond-paclitaxel for drug delivery and cancer therapy. Nanotechnology, 21: 315106#. (#Selected for Journal Highlight paper and reported by Cited 160+)

Jiang, RH, Su, WC, Liu, HF, Huang, HS, and Chao, JI* (2010) Opposite expression of securin and gamma-H2AX regulates baicalein-induced cancer cell death. Journal of Cellular Biochemistry, 111: 274-283. 

Liu, KK, Wang, CC, Cheng, CL and Chao, JI* (2009) Endocytic carboxylated nanodiamond for the labeling and tracking of cell division and differentiation in cancer and stem cells. Biomaterials, 30: 4249-4259. (Times Cited 140+)

Liu, HF, Hsiao, PW, and Chao, JI* (2008) Celecoxib induces p53-PUMA pathway for apoptosis in human colorectal cancer cells. Chemico-Biological Interactions, 176: 48-57.

Hsu, TS, Chen, C, Lee PT, Chiu, SJ, Liu, HF, and Chao, JI* (2008) 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound  induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway. Cancer Chemotherapy and Pharmacology, 62: 799-808. 

Chang, CC*, Chen, PH, Chu, HL, Lee, TC, Chou, CC, Chao, JI, Su, JY, Chen, JS, Tsai, JS, Ho, YP, Sun, KW, and Cheng, CL (2008) Laser induced popcorn-like conformational transition of nanodiamond as a nano-knife. Applied Physics Letters, 93: 3395.

Chiu, SJ*, Chao, JI, Lin, YJ, and Hsu, TS (2008) Regulation of gamma-H2AX and securin contribute to apoptosis by oxaliplatin via a p38 mitogen-activated protein kinase -dependent pathway in human colorectal cancer cells. Toxicology Letters, 179: 63-70. 

Liu, KK, Chen, MF, Chen, BI, Lee, TJF, Cheng, CL, Chang, CC, Ho, YP, and Chao, JI* (2008) Alpha-bungarotoxin binding to target cell in a developing visual system by carboxylated nanodiamond. Nanotechnology, 19: 205102. 

Chiu, SJ, Hsu, TS, and Chao, JI* (2007) Expression of securin promotes colorectal cancer cell death via a p53-independent pathway after radiation. Chemico-Biological Interactions, 170: 153–161. 

Chao, JI*, Su, WC, and Liu, HF (2007) Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT. Molecular Cancer Therapeutics, 6: 3039-3048. (Times Cited 130+)

Chao, JI, Perevedentseva, E, Chung, PH, Liu, KK, Cheng, CY, Chang, CC, and Cheng, CL* (2007) Nanometer-sized diamond particle as a probe for biolabeling. Biophysical Journal, 93: 2199-2208#. (#Selected for the cover picture)(#Selected for the Virtual Journal of Nanotechnology Environment, Health and Safety, 2007) (Times Cited 250+)

Hsiao, PW, Chang, CC, Liu, HF, Tsai, CM, Chiu, TH, and Chao, JI* (2007) Activation of p38 mitogen-activated protein kinase by celecoxib oppositely regulates survivin and gamma-H2AX in human colorectal cancer cells. Toxicology and Applied Pharmacology, 222: 97-104.

Liu, KK, Cheng, CL, Chang, CC and Chao, JI* (2007) Biocompatible and detectable carboxylated nanodiamond on human cell. Nanotechnology, 18: 325102#. (#Selected for the Virtual Journal of Nanotechnology Environment, Health and Safety, 2007)(#Reported by the Nanotechnology Web of Nanowerk) (Times Cited 250+)

Cheng, CY, Perevedentseva, E, Tu, JS, Chung, PH, Cheng, CL*, Liu, KK, Chao, JI*, Chen, PH, Chang, CC* (2007) Direct and in vitro observation of growth hormone receptor molecules in A549 human lung epithelial cells by nanodiamond labeling. Applied Physics Letters 90: 163903#. (#Selected for the Virtual Journal of Biological Physics Research) 

Chiu, SJ, Hsu, TS, and Chao, JI* (2006) Opposing securin and p53 protein expression in the oxaliplatin-induced cytotoxicity of human colorectal cancer cells. Toxicology Letters 167:122-130. 

Chao, JI*, Hsu, SH, and Tsou, TC (2006) Depletion of securin increases arsenite-induced chromosome instability and apoptosis via a p53-independent pathway. Toxicological Sciences 90: 73-86. 

Chao, JI* and Liu, HF (2006) The blockage of survivin and securin expression increases the cytochalasin B-induced cell death and growth inhibition in human cancer cells. Molecular Pharmacology 69: 154-164. 

Hsu, SH, Tsou, TC, Chiu, SJ, and Chao, JI* (2005) Inhibition of α7-nicotinic acetylcholine receptor expression by arsenite in the vascular endothelial cells. Toxicology Letters 159: 47-59. 

Lin, J, Hsiao, PW, Chiu, TH, and Chao, JI* (2005) Combination of cyclooxygenase-2 inhibitors and oxaliplatin increases the cell death and growth inhibition in human colon cancer cells. Biochemical Pharmacology 70: 658–667.

Kuo, PC, Liu, HF, and Chao, JI* (2004) Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells. Journal of Biological Chemistry 279: 55875-55885. (Times Cited 160+)

Chao, JI*, Kuo, PC, and Hsu TS (2004) Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells. Journal of Biological Chemistry 279: 20267-20276. (Times cited 120+)



Chao, JI, Perevedentseva, E, Chang, CC, Cheng, CY, Liu, KK, Chung, PH, Tu, JS, Chu, CD, Cai, SJ, Cheng, CL (2010) Protein-nanodiamond complexes for cellular surgery, in nanodiamond and its bio applications using the spectroscopic properties as probe for bio-labeling. Nanodiamonds: Applications in Biology and Nanoscale Medicine, Springer, Chapter 9: 189-224.



趙瑞益*、劉光凱、陳清漂。胺基衍生物及其醫藥組合物與用途(中華民國專利申請中)Chao, JI*, Liu, KK, and Chen, CP. 4-anilinoquinazoline derivative and albumin conjugates thereof cross-reference to related application (US Patent in Application).

Chao, JI*, Liu, KK, and Hsu, YP. Method for overcoming drug resistance of EGFR mutation an cancerous stemness of human non-small cell lung carcinoma (US Patent Application No. 15/460,500).

趙瑞益*、王舒霈、陳清漂、殷凱浩、楊進木、吳雅惠。用於促進癌細胞凋亡的化合物、其醫藥組成物及其用途(中華民國專利證書發明第I567063, 專利權有效期間2017/01/21~2034/09/04)(中華人民共和國專利證書發明第2795573, 專利權有效期間: 2018/01/26~2034/09/21)Chao, JI*, Wang, SP, Chen, C, Yin, KH, Yang, JM, Wu, YH. A compound for promoting apoptosis of cancer cells and a pharmaceutical composition containing the same and uses thereof (US Patent number US9,512,086, 2016/12/6-2035/1/14).

趙瑞益*、連芷漪、黃國柱(中華民國專利證書發明第I5888258, 專利權有效期間: 2017/06/21~2031/11/16)。經標記細胞的分離方法及其用途。Chao, JI*, Lien, ZY, and Hwang, KC. Separation method of labeled cells and uses thereof (US Patent Application No. 13/471768; US Publication No. US 20130130236 A1).

趙瑞益*、楊淳如、陳清漂。促進細胞凋亡之維生素K3衍生物、其醫藥組成物及其用途(中華民國專利證書發明第I543759, 專利權有效期間2016/08/01~2034/03/10)

楊進木*、許凱程、黃兆祺、陳文亮、黃文傑、趙瑞益。一種專一性表皮生長因子接受器之選擇性抑制劑、其醫藥組成物及其用途(中華民國專利證書發明第I536987, 專利權有效期間2016/06/11~2033/12/26)

趙瑞益*、鄭嘉良、陳清漂。包括奈米鑽石的載體、藥物及其製備的方法和用途(中華民國專利證書發明第I414309, 專利權有效期間2013/11/11~2029/7/12)Chao, JI*, Cheng, CL, and Chen, C. Medicine and carrier comprising nanodiamond, method for preparing the same and use thereof (US Application No. US 12/574958; US Publication No. US 2011/0008447 A1).

趙瑞益*、徐子勝、陳清漂、李珮亭、邱淑君。化合物在製備治療肺癌、乳腺癌及子宮頸癌之藥物用途(中華民國專利證書發明第I359018, 專利權有效期間2012/3/1~2026/7/13)Chao, JI*, Hsu, TS, Chen, C, Lee PT, and Chiu, SJ. Compound capable of cytoskeleton and induction of cell elongation and process for synthesizing the same (US Publication No. US 2008/0015221 A1).