Journal Articles and Book Chapter

  1. Tu, L.-C., Wu, M.-C.*, Chu, H.-L., Chiang, Y.-P., Kuo, C.-L., Li, H.-Y., Chang, C.-C.* (2016) Surface electromyography analysis of blepharoptosis correction by transconjunctival incisions. J. Electromyography and Kinesiology 28, 23-30.

  2. Chuang, H., Huang, L.-C. S., Kapoor, M., Liao, Y.-J., Yang, C.-L., Chang, C.-C., Wu, C.-Y., Hwu, J. R.*, Huang, T.-J.*, and Hsu, M.-H.* (2016) Design and synthesis of pyridine-pyrazole-sulfonate derivatives as potential anti-HBV agents, MedChemComm 7, 832-836.
  3. Zhang, J.F., Liang, Y.-C., Lin, X.D., Zhu, X.Y., Yan, L., Li, S.L., Yang, X., Zhu, G.Y., Rogach, A.L., Yu, P.K.N., Shi, P., Tu, L.-C., Chang, C.-C.*, Zhang, X.H.*, Chen, X.F., Zhang, W.J., and Lee, C.-S.* (2015) Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo, ACS Nano,  9, 9741-9756
  4. Chu, H.-L., Chiu, S.-C., Sung, C.-F., Tseng, W., Chang, Y.-C., Jian, W.-B.*, Chen, Y.-C.*, Yuan, C.-J., Li, H.-Y., Gu, F., Di Ventra, M.; Chang, C.-C.* (2014) Programmable redox state of nickel ion chain in DNA, Nano Letters 14, 1026-1031.
  5. Cheng T.-M., Murad Y. M., Chang C.-C.*, Yang M.-C., Baral T. N., Cowan A., Tseng S.-H., Wong A., MacKenzie R., Zhang J.* (2014) Single domain antibody against CEACAM6 inhibits proliferation, migration, invasion, and angiogenesis of pancreatic cancer cells. European Journal of Cancer 50, 713-721.
  6. Hsu M.-H.*, Chuang, H., Cheng, F.-Y., Huang, Y.-P., Han, C.-C., Chen, J.-Y, Huang, S.-C., Chen, J.-K., Wu, D.-S., Chu, H.-L., Chang, C.-C. (2014) Directly thiolated modification onto the surface of detonation nanodiamonds, ACS Appl. Mater. Interfaces. 6, 7198–7203 (IF: 6.723; Ranking: 23/260)
  7. Chu H.-L., Chen H.-W., Tseng S.-H., Hsu M.-H., Ho L.-P., Chou F.-H., Li H.-Y., Chang Y.-C., Chen P.-H., Tsai L.-Y., Chou C.-C., Chen J. S., Cheng T.-M*, Chang C.-C.* (2014) Development of growth hormone conjugated nanodiamond complex for cancer therapy. ChemMedChem 9, 1023-1029 (SCI, IF 2.968, Rank 83/255) .
  8. Chu H.-L., Chen T.-H., Wu C.-Y., Yang Y.-C., Tseng S.-H., Cheng T.-M., Ho L.-P., Tsai L.-Y., Li H.-Y., Chang C.-S., Chang C.-C.* (2014) Thermal stability and folding kinetics analysis of disordered protein securin. Journal of Thermal Analysis and Calorimetry, J. Therm. Anal. Calori.,  115, 2171-2178 (SCI, IF : 2.042, Ranking 37/74)
  9. Hsu M.-H.*, Chuang H., Cheng F.-Y., Huang Y.-P., Han C.-C., Pao K.-C., Chou S.-C., Shieh F.-K., Tsai F.-Y., Lin C.-C., Wu D.-S. and Chang C.-C., (2014) Simple and highly efficient direct thiolation of the surface of carbon nanotubes, RSC Advances  4, 14777–14780 (SCI, IF : 3.840, Ranking 33/157)
  10. Chu H.-L., Cheng T.-M., Chen H.-W., Chou F.-H.,Chang Y.-C., Lin H.-Y.,Liu S.-Y., Liang Y.-C., Hsu M.-H., Wu D.-S., Li H.-Y., Ho L.-P., Wu P.-C., Chen F.-R., Chen G.-S., Shieh D.-B., Chang C.-S., Su C.-H., Yao Z., and Chang C.-C.* (2013) Synthesis of apolipoprotein B lipoparticles to deliver hydrophobic/amphiphilic materials. ACS Appl. Mater. Interfaces 5, 7509-7516. (IF: 6.723; Ranking: 23/260)
  11. Li H.-Y., Tseng S.-H., Cheng T.-M., Chu H.-L., Lu Y.-N., Wang F.-Y., Tsai L.-Y., Shieh J.-Y., Yang J.-Y., Juan C.-C., Tu L.-C., Chang C.-C.* (2013) Rapid and highly sensitive detection of Enterovirus 71 by using nanogold-enhanced electrochemical impedance spectroscopy. Nanotechnology 24, 285102. (IF: 3.821; Ranking: 20/144)
  12. Yu S.-Y., Liu H.-F., Wang S.-P, Chang C.-C., Tsai C.-M., Chao J.-I.* (2013) Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells Chemico-Biological Interactions 23, 412-422.
  13. Svanidze A.V., Koludarov I. P., Lushnikov S. G., Asenbaum A., Pruner C., Aliev F. M., Chang C.-C., Kan L-S (2012) Specific features of the temperature behavior of lysozyme diffusivity in solutions with different protein concentrations. J. Mol. Liquid 168, 7-11(IF: 1.580; 20/32; SCI).
  14. Qin W., Sundaram M., Wang Y., Zhou H., Shumei Zhong, Chang C-C, Manhas S., Yao E. F., Parks R. J., McFie P. J., Stone S. J., Jiang Z. G., Wang C., Figeys D., Jia W., and Yao Z, (2011) Missense mutation in APOC3 within the C-terminal lipid-binding domain of human apoC-III results in impaired assembly and secretion of triacylglycerol-rich very low density lipoproteins: Evidence that APOC-III plays a major role in the formation of lipid precursors within the microsomal lumen. J. Biol. Chem. 286, 27769-27780 (SCI)
  15. Tseng S-H, JangJian P-C, Tsai C-M, Cheng T-M, Chu H-L, Chang Y-C, Chung W-H, and Chang, C-C* (2011) Ni2+ enhanced charge transport via p-p stacking corridor in metallic-DNA. Biophy. J. 100, 1042-1048. (SCI, IF: 4.218, 18/73)
  16. Cheng T-M, Lee T-C, Tseng S-H, Chu H.L., Pan J-P, Chang C-C* (2011) Human Haptoglobin Phenotypes and Concentration Determination by Nanogold-enhanced Electrochemical Impedance Spectroscopy, Nanotechnology 22, 245105. (SCI, IF: 3.644, 30/222)
  17. Liu Y.-K., Lin Y.-L., Chen C.-H., Lin C.-M., Ma K.-L., Chou F.-H., Tsai J.-S., Lin H.-Y., Chen F.-R., Cheng T.-L., Chang C.-C., Liao K.-W.*,  (2011) A unique and potent protein binding nature of liposome containing polyethylenimine and polyethylene glycol: a nondisplaceable property. Biotechnology and Bioengineering, 108, 1318-1327 (SCI, IF: 3.7, 34/160)
  18. Cheng T.-M., Mao S. J.T., Lai S.-T., Chang C.-C., Yang M.-C., Chen N.-C., Chou S.-C., Pan J.-P. (2011) Hemoglobin-induced oxidative stress is associated with both endogenous peroxidase activity and H2O2 generation from polyunsaturated fatty acids. Free Radical Research 45, 303-316 (SCI, IF: 2.805, 143/286)
  19.  KW Sun and C-C Chang (2011) Bridging Biomolecules with Nanoelectronics in “Handbook of Nanophysics: Nanoelectronics and Nanophotonics” Taylor & Francis Group.
  20. P.-C. JangJian, S.-H. Tseng, C.-M. Tsai, T.-M. Cheng, H.-L. Chu and C.-C. Chang*. (2010) DNA: a native nano-wire in nature. Instruments Today, 177, 61-71.
  21. J.I. Chao, E. Perevedentseva, C.C. Chang, C.Y. Cheng, K.K. Liu, P.H. Chung, J.S. Tu, C.D. Chu, S.J. Cai, and C.L. Cheng (2010) Protein–Nanodiamond Complexes for Cellular Surgery: Nanodiamond and Its Bioapplications Using the Spectroscopic Properties as Probe for Biolabeling. In Nanodiamonds:Applications in Biology and Nanoscale Medicine (D Ho Ed.), pp 189-224. Springer, New York.
  22. W. K. Liu, A. Adnan, A. M. Kopacz, M. Hallikainen, D. Ho, R. Lam, J. Lee, T. Belytschko, G. Schatz, Y.H. T. Tzeng, Y.-J. Kim, S. Baik, M. K. Kim, T. Kim, J.H. Lee, E.-S. Hwang, S. Im, E. Ōsawa, A. Barnard, H.-C. Chang, C.-C. Chang, and E. Oñate (2010) Design of Nanodiamond Based Drug Delivery Patch for Cancer Therapeutics and Imaging Applications, pp 249-284. Springer, New York.
  23. Lin C.-Y., Huang Y.-S., Li C.-H., Hsieh Y.-T., He P.-J., Hsu W.-T., Yeh Y.-C., Chiang F.-H., Wu M.-S., Chang C.-C., Liao K.-W.* (2009) Characterizing the polymeric status of Helicobacter pylori heat shock protein 60. Biochem. Biophys. Res. Commun, 388, 283-289.
  24. Jangjian P.C., Liu T-F, Tsai C.-M., Li M.-Y., Tsai M.-S.,Tseng S.-H., Cheng T.-M. and Chang C.-C.* (2009) DNA mismatch detection by metal ion enhanced impedance analysis. Chinese J. Physics (Accepted) (SCI, IF=0.27).
  25. Li M, Huang Y-S, Jeng U-S*, Hsu I-J*, Wu Y-C-S, Lai Y-H, Su C-H, Lee J-F, Wang Y, and Chang C-C (2009) Resonant X-ray Scattering and Absorption for the Global and Local Structures of Cu-modified Metallothioneins in Solution. Biophysical J. 97, 609-617.
  26. JangJian P.-C., Liu T.-F., Li M.-Y., Tsai M.-S., Chang C.-C.* (2009) Room temperature negative differential resistance in DNA-based molecular devices. Applied Physics Letters. 94, 043105 This paper has been selected for publication in Virtual Journal of Nanoscale Science & Technology (2009) and This paper has been selected in Virtual Journal of Biological Physics Research (2009), too.
  27. Liu C.-P., Wey M.-T., Chang C.-C.*,Kan L.-S. (2009) Direct observation of single molecule conformational change of tight-turn paperclip DNA triplex in solution. Applied Biochemistry and Biotechnology. 159, 261-269.
  28. Chang C.-C.*,Chen P.-H.,Chu H.-L.,Lee T.-C., Chou C.-C., Chao J.-I., Su C.-Y., Chen J. S.,Tsai J.-S.,Tsai C.-M., Ho Y.-P., Sun K.-W., Cheng C.-L., Chen F.-R. (2008) Laser induced popcorn-like conformational transition of nano-diamond as a nano-knife. Applied Physics Letters. 93, 033905. This paper has been selected for publication in Virtual Journal of Biological Physics Research (2008)
  29. Jang Jian P-C, Liu T-F, Tsai C-M, Tasi M-S, Chang C-C * (2008) Ni2+ doping DNA: a semiconducting biopolymer. Nanotechnology 19, 355703. (IF: 3.3; Ranking: 2/66)
  30. Liu K.-K., Chen M.-F., Chen P.-Y., Lee T. J.F., Cheng C.-L., Chang C.-C., Ho Y.-P. ,Chao J.-I. (2008) Alpha-bungarotoxin binding to target cell in a developing visual system by carboxylated nanodiamond. Nanotechnology, 19 205102. (IF: 3.3; Ranking: 2/66)
  31. Chang C.-C.*, Lin P.-Y.,Chen Y.-F., Chang C.-S., Kan L.-S. (2007) Direct visualization of triplex DNA molecular dynamics by fluorescence resonance energy transfer and atomic force microscopy measurements. Applied Physics Letters 91, 213901 (IF: 3.977; Ranking 6/84). This paper has been selected in Virtual Journal of Biological Physics Research (2007)
  32. Sun K.W.* and Chang C.C. (2007) Patterning of magnetic molecular self-assembly on semiconductor substrates, Journal of Physics and Chemistry of Solids 68, p.1211-1214. (IF:1.164; Ranking:34/58)
  33. Liu, K.-K., Cheng, C.-L., Chang C.-C., and Chao, J.-I.* (2007) Biocompatible and detectable carboxylated nanodiamond on human cell. Nanotechnology. 18, 325102 (IF: 3.037; Ranking: 2/66)
  34. Chao J.-I, Perevedentseva E., Chung P.- H., Liu K.- K., Cheng C.-Y., Chang C.-C., Cheng C. - L*. (2007) Nanometer-Sized Diamond Particle as a Probe for Bio labeling. Biophysics J. 93, 2199-2208. Cover story (IF: 4.757; Ranking: 8/66) This paper has been selected in The Virtual Journal of Nanotechnology Environment, Health and Safety (2007)
  35. Chang C.-C. and Kan L.-S. (2007) Protein folding: an antagonistic reaction of spontaneous folding and diffusion limited aggregation in nature. Chinese. J. Phys. Accepted. (IF: 0.238; Ranking: 66/68)
  36. Hsiao P.-W., Chang C.-C., Liu H.-F., Tsai C.-M., Chiu T.-H., and Chao J.-I (2007) Activation of p38 mitogen-activated protein kinase by celecoxib oppositely regulates survivin and gamma-H2AX in human colorectal cancer cells. Toxicology and Applied Pharmacology. 222, 97-104. (IF: 4.722; Ranking 4/76)
  37. Cheng C. - Y., Perevedentseva E., Tu J. - S., Chung P. - H., Cheng C. - L*., Liu K.-K., Chao J.-I.*, Chen P.-H., Chang C.-C.* (2007) Direct and In vitro observation of growth hormone receptor molecules in A549 human lung epithelial cells by nanodiamond labeling. Applied Physics Letters, 90, 163903. (SCI). (IF: 3.977; Ranking 6/84) This paper has been selected in Virtual Journal of Biological Physics Research (2007)
  38. Chang C.-C., Sun K.-W., Lee S.-F., Kan L.-S (2007) Self-assembled Molecular Magnets on Patterned Silicon Substrates: Bridging Bio-molecules with Nanoelectronics. Biomaterials 28, 1941-7. (SCI) Leading opinion. (IF: 6.646; Ranking: 2/42; 1/14)
  39. Chang CC*, Chen P.H, Yeh YC, Tsai CM, Su JY, Chen JS (2007) The application of nano particles in biomedicine. Instruments Today, 28, 27-37.
  40. Yang CH, Wang CY, Chen KC, Chang CC, Sun KW (2007) Synthesis novel biomaterials by molecular self-assembly. Electronics J.138, 182-190.
  41. Chang C.-C., Sun K.-W., Kan L.-S, Kuan C.H. (2006) Guided Three-dimensional Molecular Self-assembly on Silicon Substrates. Applied Physics Letters 88, 263104. This paper has been selected for the Volume 14, Issue 2 of Virtual Journal of Biological Physics Research. This paper has been selected for the Volume 12, Issue 1, 2006 issue of Virtual Journal of Nanoscale Science & Technology, too. (SCI) (NSC 94-2112-M-009-039)
  42. Chang C.-C. *, Lee S.-F.; Sun K.-W., Ho C.-C.; Chen Y.-T.; Chang C.-H., Kan L.-S. (2006) Mn,Cd-metallothionein-2: A room temperature magnetic protein. Biochem. Biophys. Res. Commun. 340, 1134-1138. (SCI) (NSC 94-2112-M-009-039).
  43. Chang C.-C.*., Lin C.-S.,Chen M.-C.,Liu Y.-C., Huang Y.-F., Lin P.-Y.,Chen Y.-F,Chang C.-S., Kan L.-S.(2006) Folding and Structural Characterization of Recombinant Cyclin-dependent Kinase Inhibitor p21(Cip1, Waf1, Sdi1), Biophysical Reviews and Letters. 1, 45-56. (NSC 94-2112-M-009-039)
  44. Chung P.-H., Perevedentseva E., Tu J.-S., Chang C.-C.,Cheng C.-L. (2006) Spectroscopic study of bio-functionalized nanodiamonds. Diamond and Related Materials. 15, 622-625. (SCI) (NSC 94-2112-M-009-039)
  45. Chang C.-C.* (2006) Protein forlding and aggregation. Physics bimonth, 28, 668-675.
  46. 張家靖.,陳冠舟,孫建文(2006) 矽基版表面蛋白質奈米柱之自組裝, Chemistry (The Chinese Chem. Soc., Taipei), 64, 477-482
  47. Chang CC*, Lin PY, Yeh XC, Deng KH, Ho YP and Kan LS* (2005) Protein folding stabilizing time measurement: a direct folding process and three-dimensional random walk simulation. Biochem. Biophys. Res. Commun. 328, 845-850. (SCI) (NSC 93-2112-M-259-001)
  48. Chang C.-C.*, and Kan L.-S. (2005) Manipulation and Characterization of Nano-Biomolecules, Symposium on Nano Device Technology 2005. pp95~98.
  49. Chang CC*, Yeh XC, Lee HT, Lin PY, Kan LS*(2004) Refolding of lysozyme by quasistatic and direct dilution reaction paths: A first-order-like state transition. Physical Review E.70, 011904 (SCI) (NSC 92-2112-M-259-016) This paper has been selected for the Virtual Journal of Biological Physics Research 8, issue 2 (July 15, 2004).
  50. Chang CC*, Cheng MS, Su YC, and Kan LS* (2003) A first-order-like state transition for recombinant protein folding. J. Biomol. Struct. Dyn. 21, 247~255 (SCI) (NSC 91-2112-M-259-009).
  51. Liu YL, Lee HT, Chang CC *, and Kan LS * (2003) Reversible folding of cysteine-rich metallothionein by an over-critical reaction path. Biochem. Biophys. Res. Commun. 306, 59-63. (SCI) (NSC 91-2112-M-259-009)
  52. Chen HM, Chan SC, Lee JC, Chang CC, Murugan M, Jack RW. (2003) Transmission electron microscopic observations of membrane effects of antibiotic cecropin B on Escherichia coli. Microsc Res Tech. 62, 423-430.
  53. Chang CC*, Su YC, Cheng MS and Kan LS* (2002) Protein folding by quasi-static-like process-a first order state transition. PHYSICAL REVIEW E 66, 021903 (SCI) (90-2113-M-259-013). This paper has been selected for the Virtual Journal of Biological Physics Research.
  54. Chang CC, Tsai, CT and Chang, CY (2002) Structural restoration of inactive recombinant fish growth hormones by chemical chaperonin and solvent restraint approaches. Protein Engineering 15: 437-441 (SCI)
  55. Tzang BS, Lai YC, Hsu M, Chang HW, Chang CC, Huang PC and Liu YC (1999) Function and sequence analyses of tumor suppressor gene p53 of CHO.K1 cell. DNA and Cell Biol. 18:315-321.(SCI)
  56. Chang CC and Huang PC (1999) Simulation of Zn/Cd binding in mammalian metallothionein domains. In Metallothionein IV (Klaassen CD ed.) Pp 45-49.Birkhauser Verlag publish, Boston.
  57. Chang CC, Liao WF and Huang PC (1998) Cysteine contributions to binding preference for Zn/Cd in -domain of metallothionein. Protein Engineering 11: 40-46. (SCI)
  58. Chang CC and Huang PC (1996) Semi-empirical simulation of Zn/Cd binding site preference in the metal binding domains of mammalian metallothionein. Protein Eng 9:1165-1172. (SCI)
  59. Liu YC, Chen GS and Chang CC (1995) Mutation of gene required for cell spreading is corrected by serum or factor secreted by normal cells. In Vitro Cell Dev. Biol.-Animal 31: 571-573. (SCI)
  60. Chang CC, Chou YC, and Wu WG (1994) SERS study of the transport of ATP through the DPPC bilayer. Proc. Natl. Sci. Counc. ROC(A)18: 163-167.
  61. Huang JK and Chang CC (1994) Computer simulation of enzymatic reactions. Chemistry (Taiwan) 52: 246-250.

 International Invited Talk

  1. 9th AFMC international Medical Chemistry Symposium, Invited Speaker and Section Chair, Oct 15-18, 2013

  2. IEEE NMDC (Nanotechnology Materials and Devices conference) 2013, Oct. 6-9, 2013

  3. 10th US Air Force-Taiwan Nanoscience Workshop and Program Review, Aug 20-22, 2013

  4. Leory Hood excellent academic lectures, Mar. 27, 2013
  5. 8th Biology Inspired Theoretical Science, June, 22, 2012
  6. 9th Taiwan/U.S. Air Force Nanoscience Workshop April 17, 2012
  7. WIN seminar, Waterloo Institute for Nanotechnology, University of Waterloo , Canada, Oct 27, 2011
  8. Department seminar, Department of Biochemistry, Microbiology, Immunology, University of Ottawa, Canada, Oct 28, 2011
  9. Institute for Biological Sciences, National Research Council (NRC-IBS) Aug 18, 2010
  10. Department seminar, Department of Biochemistry, Microbiology, Immunology, University of Ottawa, Canada, Aug 03, 2010
  11. Department of Chemistry and Biochemistry, Florida International University, USA, Feb 5th, 201
  12. The 1st World Class University Joint-Workshop pn SBE&S, Sungkyunkwan Univ. Korea (2009)
  13. Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Canada (2008)
  14. Taiwan-uOttawa International Workshop. Ottawa, Canada (2008)
  15. Joint 2008 Workshop on Innovations and Advanced Studies (IIAS) & 2008 Taiwan (NSC) – US (NSF) Workshop on Simulation Based Engineering & Science (SBE&S) on Biomedicine, Energy, Enabling Materials, and Micro-Nanotechnology. Tianan, Taiwan (2008)
  16. Third China-Singapore Joint Symposium on Research Frontiers in Physics, Xiamen, China (2007)
  17. Opportunities and Challenges for Physicists in Quantitative and Systemic Biology, Hong Kong (2006)


  1. Reconstituted apoB lipoparticles as drug, amphiphilic and hydrophobic materials delivery vehicle (Applying)
  2. Bio-nanowire device and method of fabricating the same cross-reference to related application (Pending)
  3. LED integrated fiber biological detection module (Pending)
  4. Nano-magnetic protein. (2007)
  5. Application of Fishes Growth Hormone Genes and Their Recombinant DNA. (2003)